![]() ![]() Over 80% of patients with ARVC will have an abnormal ECG. 49 The diagnosis is fulfilled in the presence of two major criteria, one major plus two minor criteria, or four minor criteria from different groups. The original (1994) and the revised (2010) Task Force Criteria for diagnosis of ARVC are based on major and minor criteria encompassing familial/genetic, ECG, arrhythmic, morphofunctional ventricular and histopathological features. 44 45 Contribution as a cause of SCDĪccording to data from the Veneto region of Italy where postmortem investigation of young sudden death victims is performed systematically, ARVC is a leading cause of sport-related sudden death accounting for approximately one-fourth of fatalities in young competitive athletes.3 Data from the USA, notably without a mandatory registry for SCD in athletes, suggest that ARVC is a less common cause of SCD. 46–48 The prevalence of familial ARVC is estimated at 1 : 2000–1 : 5000 persons. 44 45 In addition, there is emerging evidence that intense endurance sports may lead to a similar phenotype (with similar prognosis) in the absence of desmosomal mutations, so-called exercise-induced ARVC, which may be the result of increased RV wall stress during exercise. Mutations in the desmosomal genes account for approximately 50% of ARVC cases. ![]() Variants with predominantly LV involvement are described in about 10% of patients (hence the alternative term of arrhythmogenic cardiomyopathy). Progressive dilation/dysfunction predominantly involves the right ventricle with involvement of the left ventricle in late-stage disease. Deel II: Arrhythmogenic right ventricular cardiomyopathyĪRVC is an inherited heart muscle disease characterised by fibro-fatty replacement of right ventricular myocardium and corollary life-threatening ventricular arrhythmias or SCD, mostly in young people and athletes. Voor de complete introductie zie Sport & Geneeskunde 3-2013, pag. Hierin kunt u lezen dat differentiatie tussen fysiologie en pathologie op het ECG bij een sporter soms zeer moeilijk kan zijn, vooral omdat het ECG van een sporter bedrieglijk veel kan lijken op dat van iemand met CMP. In dit deel wordt het ECG bij sporters met een cardiomyopathie onder de loep genomen. Na publicatie (met toestemming) van de eerste twee delen van de “ECG bundel”, overgenomen uit BJSM 2013 in Sport & Geneeskunde, volgt hier het tweede deel van deel 3.
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